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| CHEMICAL INFORMATION | |||
|---|---|---|---|
| Name | Semaglutide | CAS No. | 910463-68-2 |
| CAT No. | YD0002 | Storage | 3 years -20°C powder |
| Formula | C187H291N45O59 | 2 years -80°C in solvent | |
| Molecular | 4113.64 | Purity | Local GMP |
| Description | Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1 | ||
| In vitro | Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844. 2. Zhang L, et al. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides. 2018 Oct;71:70-80. 3. Dhillon S, et al. Semaglutide: First Global Approval. Drugs. 2018 Feb;78(2):275-284. | ||
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